by OpticElastograph

A platform designed for processing OCT data by laboratory staff at universities, clinics, and hospitals to study the physical parameters of biological tissues.


  • Elastography
    Mapping the Young's modulus using a compression OCE
  • Strain mapping
    Mapping of mechanical, laser-induced, osmotic deformations
  • Attenuation
    Mapping the spatially resolved attenuation of the OCT signal by the Vermeer at all. method taking into account the noise level
  • Speckle contrast
    Speckle contrast mapping taking into account signal attenuation
  • Angiography

    Vascular network mapping
  • Lymphography
    Mapping the network of lymphatic vessels
  • Simulation
    Generation of model OCT-scans based on a wave approach that takes into account the formation of an OCT signal
  • Annotation
    Segmentation of scan areas based on attenuation map





Due to the high sensitivity of the stiffness of biological tissues to its different structures and states OCE is of great interest.

  • High diagnostic contrast
    The high contrast and excellent detailed comparison of elastographic images with histological images makes it possible to provide promising support for standard histology using optical coherence elastography (OCE).
  • Non-invasive fast scan
    OCE in vivo monitoring allows real-time scanning of tissues without taking regular biopsies using the traditional method, which eliminates the need for a huge amount of histological studies.
  • Cell group order resolution
    OCE can serve as a tool for high-resolution morphological segmentation.


  • 1
    The implementation of the correlation search showed low efficiency due to the strong decorrelation caused by the interference nature of the structural OCT scan speckles. Increasing decorrelation with increasing strain level, the ability to work only with small strains subject to strong additive noise distortions, became the main reasons for the results of little practical interest. Significant progress in deformation mapping using OCT has been achieved in recent years due to the transition to the phase method. The method is based on the calculation of the phase variation between scans taken in the initial and deformed state of the tissue, and the further determination of the axial gradient responsible for the displacement of the scatterers. The method was called vector method [1], the main advantages of this method are the resistance to errors caused by phase ambiguity and the low impact of low-amplitude pixels with a noise phase on the determination of offsets. Both of these factors introduced significant distortions when using a simple phase method.

    [1] “Vector method for strain estimation in phase-sensitive optical coherence elastography” A.L. Matveyev, L.A. Matveev, A.A. Sovetsky, G.V. Gelikonov, A.A. Moiseev, V.Y. Zaitsev, Laser Physics Letters, 15(6), 065603 (2018) (Q2)

  • 2
    After obtaining interframe deformations by the vector method, the correct accumulation of deformations plays an important role[1]. The process must take into account the magnitude of interframe deformations.

    [1] “Manually-operated compressional optical coherence elastography with effective aperiodic averaging: demonstrations for corneal and cartilaginous tissues” AA Sovetsky, AL Matveyev, LA Matveev, DV Shabanov, VY Zaitsev, Laser Physics Letters, 15(8), 085602 (2018) (Q2)

  • 3
    With long-term compression, to obtain biomechanical dependences at high pressure, tracking of superpixel displacements of scatterers is required in order to avoid strong distortions of the results [1].

    [1] "Mapping Large Strains in Phase-Sensitive OCT: Key Role of Supra-Pixel Displacement Tracking in Incremental Strain Evaluation." SOVETSKY, Alexander A. et al., Journal of Biomedical Photonics & Engineering, [S.l.], v. 8, n. 3, p. 030304, sep. 2022. ISSN 2411-2844. Available at: <>. Date accessed: 07 nov. 2022. (Q3)

  • 4
    Studies of the dependence of Young's modulus (stiffness) of biological tissues on the magnitude of their deformation showed a predominantly strong non-linear dependence of the pressure-strain curve for most biological tissues. The construction of elastograms at standardized pressure makes it possible to obtain a repeatable picture of the internal distribution of biological tissue stiffness with the possibility of correct segmentation of biological tissue into morphological subtypes [1].

    [1] “Full-optical method of local stress standardization to exclude nonlinearity-related ambiguity of elasticity estimation in compressional optical coherence elastography” A A Sovetsky, A L Matveyev, L A Matveev, E V Gubarkova, A A Plekhanov, M A Sirotkina, N D Gladkova and V Y Zaitsev, Laser Physics Letters Volume 17, Number 6 (2020) (Q2)

For cooperation:

Alexander Sovetsky
Phone: +7 987 397 52 79